A city of monsters with no humans called Monstropolis centers around the city's power company, Monsters, Inc. The lovable, confident, tough, furry blue behemoth-like giant monster named James P. Sullivan (better known as Sulley) and his wisecracking best friend, short, green cyclops monster Mike Wazowski, discover what happens when the real world interacts with theirs in the form of a 2-year-old baby girl dubbed "Boo," who accidentally sneaks into the monster world with Sulley one night. And now it's up to Sulley and Mike to send Boo back in her door before anybody finds out, especially two evil villains such as Sulley's main rival as a scarer, chameleon-like Randall (a monster that Boo is very afraid of), who possesses the ability to change the color of his skin, and Mike and Sulley's boss Mr. Waternoose, the chairman and chief executive officer of Monsters, Inc.

Scrat's epic pursuit of his elusive acorn catapults him outside of Earth, where he accidentally sets off a series of cosmic events that transform and threaten the planet. To save themselves from peril, Manny, Sid, Diego, and the rest of the herd leave their home and embark on a quest full of thrills and spills, highs and lows, laughter and adventure while traveling to exotic new lands and encountering a host of colorful new characters.

In 1970s Iran, Marjane 'Marji' Statrapi watches events through her young eyes and her idealistic family of a long dream being fulfilled of the hated Shah's defeat in the Iranian Revolution of 1979. However as Marji grows up, she witnesses first hand how the new Iran, now ruled by Islamic fundamentalists, has become a repressive tyranny on its own. With Marji dangerously refusing to remain silent at this injustice, her parents send her abroad to Vienna to study for a better life. However, this change proves an equally difficult trial with the young woman finding herself in a different culture loaded with abrasive characters and profound disappointments that deeply trouble her. Even when she returns home, Marji finds that both she and homeland have changed too much and the young woman and her loving family must decide where she truly belongs.

Max faces some major changes after his owner Katie gets married and now has a child. On a family trip to the countryside, Max meets a farm dog named Rooster, and both attempt to overcome his fears. Meanwhile, Gidget tries to rescue Max's favorite toy from a cat-packed apartment, and Snowball sets on a mission to free a white tiger named Hu from a circus.