Dr. Ryan Stone (Sandra Bullock) is a brilliant medical engineer on her first shuttle mission, with veteran astronaut Matt Kowalski (George Clooney) in command of his last flight before retiring. But on a seemingly routine spacewalk, disaster strikes. The shuttle is destroyed, leaving Stone and Kowalsky completely alone - tethered to nothing but each other and spiraling out into the blackness.

After a gentle alien becomes stranded on Earth, the being is discovered and befriended by a young boy named Elliott. Bringing the extraterrestrial into his suburban California house, Elliott introduces E.T., as the alien is dubbed, to his brother and his little sister, Gertie, and the children decide to keep its existence a secret. Soon, however, E.T. falls ill, resulting in government intervention and a dire situation for both Elliott and the alien.

Fate deals young orphan Matt Murdock a strange hand when he is doused with hazardous waste. The accident leaves Matt blind but also gives him a heightened "radar sense" that allows him to "see" far better than any man. Years later Murdock has grown into a man and becomes a respected criminal attorney. But after he's done his "day job" Matt takes on a secret identity as "The Man Without Fear," Daredevil, the masked avenger that patrols the neighborhood of Hell's Kitchen and New York City to combat the injustice that he cannot tackle in the courtroom.

Batman, Batgirl and Robin forge an alliance with The Teenage Mutant Ninja Turtles to fight against the Turtles' sworn enemy, The Shredder, who has teamed up with Ra's Al Ghul and The League Of Assassins.