Wayne Gretzky (no relation) is a vampire who can't grow his teeth. His impotence began when he inadvertently killed Mary Lipinsky, the love of his life, 300 years ago. To take his mind off the pain, he teaches college history - who better? Attempting to regain his full power, he enlists help from his friend and colleague, Dr. Levine (Gary Cole). Nothing works until a new semester brings freshman Chris Keller. She's a dead ringer for Mary and they have a lurid affair, while rumors fly around the campus. But it all sours when he turns Chris into a vampire and her newfound bloodlust spins out of control in a bloody rampage, making the rumors a little too real.

Best friends Dave, Mike, Cyril and Moocher have just graduated from high school. Living in the college town of Bloomington, Indiana, they are considered "cutters": the working class of the town so named since most of the middle aged generation, such as their parents, worked at the local limestone quarry, which is now a swimming hole. There is great animosity between the cutters and the generally wealthy Indiana University students, each group who have their own turf in town. The dichotomy is that the limestone was used to build the university, which is now seen as being too good for the locals who built it. Although each of the four is a totally different personality from the other three, they also have in common the fact of being unfocused and unmotivated in life. The one slight exception is Dave. Although he has no job and doesn't know what to do with his life, he is a champion bicycle racer. He idolizes the Italian cycling team so much he pretends to be Italian, much to the chagrin...

Kevin Chan (aka Jackie) is a Hong-Kong cop, who scores his first big hit by virtually single-handedly capturing and arresting a big drug- lord. Of course, the drug-lord isn't too happy about this, and frames Kevin with the murder of another cop (who happened to be on the take). Kevin has to clear his name, whilst keeping himself from getting killed or arrested, and keeping his girlfriend from leaving him.

Two nerdy Caltech students hook up and end up on a journey throughout California after they find out one is pregnant with the other's twins.