War brews over Warsaw in 1939, and while life is still running its course, the Germans are slowly beginning to make their presence felt, with Hitler secretly preparing for the German invasion of Poland. Under those circumstances, the young couple of Jan and Antonina Zabinski continue their daily routine as owners and keepers of the Warsaw Zoo, but soon, as German Luftwaffe's Stukas hammer the Polish capital, their life's work together with the city, will turn to ashes. However, with the zoo liquidated for the war effort and many of its animals tragically perished, what was once an animals' zoo, will now serve as a sanctuary where Antonina, the humanist veterinarian, and Jan can hide the persecuted Polish Jews in plain sight until safe houses are found. That was Jan and Antonina's formidable, yet perilous plan, who regardless of the consequences, refused to wither before the Nazi menace, took matters into their own hands and sheltered 300 Jews under the Germans' noses.

Homer is an orphan in remote St. Cloud, Maine. Never adopted, he becomes the favorite of orphanage director Dr. Larch, who imparts his full medical knowledge on Homer, who becomes a skilled, albeit unlicensed, physician. But Homer yearns for a self-chosen life outside the orphanage. When Wally and pregnant Candy visit the orphanage Dr. Larch provides medically safe, albeit illegal, abortions Homer leaves with them to work on Wally's family apple farm. Wally goes off to war, leaving Homer and Candy alone together. What will Homer learn about life and love in the cider house? What of the destiny that Dr. Larch has planned for him?

The film is set in a house occupied by a collection of social misfits. The main storyline is that of a strange musician's relationship with a girl, their drug use and his band. These events are surrounded by a chaotic myriad of sub-plots. A homicidal chainsaw maniac's lust for his machine and a T.V station's offer of money in return for a piece of the Skylab satellite that has fallen to earth are just two. The film is composed of small fragments in the lives of its inhabitants, each following onto the next, sometimes overlapping and ending in tragedy.

When Suzanne Stein has a genetic analysis done on her unborn child, she discovers that although she has a healthy baby, the child will most likely be born gay, like her brother, David. She must decide whether to keep the child, or to have an abortion. Her family enters a crisis about love and acceptance as she makes this difficult choice.